Chronic Osteomyelitis of the Humeral Head Associated with Sickle Cell Disease

Authors

Keywords:

chronic osteomyelitis; methicillin-resistant Staphylococcus aureus; sickle cell disease.

Abstract

Introduction: Chronic osteomyelitis in pediatric patients with sickle cell disease represents a diagnostic and therapeutic challenge, especially when caused by resistant microorganisms such as methicillin-resistant Staphylococcus aureus.

Objective: To describe the diagnosis, therapeutic management, and clinical course of a case of chronic osteomyelitis of the humeral head in a patient with sickle cell disease.

Case report: An eight-year-old girl with sickle cell disease developed chronic osteomyelitis of the left humeral head. The diagnosis was based on clinical, imaging, and microbiological findings. Management included prolonged antibiotic therapy and surgical debridement, with a favorable outcome.

Conclusions: This case highlights the importance of considering resistant pathogens in immunocompromised patients and the need for a multidisciplinary approach.

Keywords: chronic osteomyelitis; methicillin-resistant Staphylococcus aureus; sickle cell disease.

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Author Biography

Yusdali Perez Monterrey, Universidad de ciencias médicas de ciego de Ávila

Jefe de departamento, Especialista en ortopedia y traumatología

References

1. Odièvre MH, Quinet B. Drepanocitosis en el niño. EMC-Pediatría. 2021;56(1):1-16. DOI: https://doi.org/10.1016/S1245-1789(21)44719-0

2. Weisman JK, Nickel R, Darbari D, Hanisch B, Diab Y. Características y resultados de la osteomielitis en niños con anemia de células falciformes: experiencia de 10 años en un solo centro. Pediatr Blood Cancer. 2020;67:e28225. DOI: https://doi.org/10.1002/pbc.28225

3. Allende JM, Barbero M, García Sánchez M, Arranz Caso A. Osteomielitis. Medicine. 2022;13(52):3041-9. DOI: https://doi.org/10.1016/j.med.2022.03.012

4. Vijayakumar AB, Reddy YP, Suphala B, Gopalakrishnan A, Vinod Kumar CS. Perfil microbiológico y antibiótico de la osteomielitis en un hospital de tercer nivel. Int Surg J. 2021 [acceso 17/07/2025];8(3):910-4. Disponible en: https://www.ijsurgery.com/index.php/isj/article/view/7092

5. Scourfield LEA, Nardo-Marino A, Williams TN, Rees DC. Infections in sickle cell disease. Haematologica. 2025;110(3):546-61. DOI: https://doi.org/10.3324/haematol.2024.285066

6. Kao CM, Yee ME, Maillis A, Lai K, Bakshi N, Rostad BS, et al. Microbiology and radiographic features of osteomyelitis in pediatric sickle cell disease. Pediatr Blood Cancer. 2020;67(10):e28517. DOI: https://doi.org/10.1002/pbc.28517

7. Fontalis A, Hughes M, Anwar F, Padman M, Theocharopoulos N, Lavy C. The challenge of differentiating vaso-occlusive crises from osteomyelitis in children with sickle cell disease and bone pain: A 15-year retrospective review. J Child Orthop. 2019;13(1):33-9. DOI: https://doi.org/10.1302/1863-2548.12.180094

8. Yolande D, Tufong K, Jules T, Mayah A, Charlotte E, Njinkui D, et al. Osteomielitis en niños con anemia de células falciformes: un diagnóstico complejo: informe de un caso de Camerún. Open J Pediatr. 2021;11:208-14. DOI: https://doi.org/10.4236/ojped.2021.112020

9. Délicat-Loembet LM, Nzengui GF, Akue JP, M’Ba RR, Ntoumi F. Bacterial infection in the sickle cell population: development and enabling factors. Microorganisms. 2023;11(4):859. DOI: https://doi.org/10.3390/microorganisms11040859

10. Bolo S, Mishra T, Eziri U, Calvo Leon T, Mankar D, Navarrete F, et al. Sickle cell disease: A 75-year journey. Gene Protein Dis. 2025;4(1):4361. DOI: https://doi.org/10.36922/gpd.4361

11. Woods CR, Bradley JS, Chatterjee A, Copley LA, Robinson J, Kronman MP, et al. Clinical practice guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics. J Pediatric Infect Dis Soc. 2021;10(8):801-44. DOI: https://doi.org/10.1093/jpids/piab027

12. Berger E, Saunders N, Wang L, Friedman JN. Sickle cell disease in children: differentiating osteomyelitis from vaso-occlusive crisis. Arch Pediatr Adolesc Med. 2009;163(3):251-5. DOI: https://doi.org/10.1001/archpediatrics.2008.545

13. Peltola H, Pääkkönen M. Acute osteomyelitis in children. N Engl J Med. 2014;370(4):352-60. DOI: https://doi.org/10.1056/NEJMra1213956

Published

2026-10-24

How to Cite

1.
Perez Monterrey Y, Peñaranda Calzado MA, Sánchez Ramos V. Chronic Osteomyelitis of the Humeral Head Associated with Sickle Cell Disease. Revista Cubana de Ortopedia y Traumatologí­a [Internet]. 2026 Oct. 24 [cited 2026 Oct. 26];40. Available from: https://revortopedia.sld.cu/index.php/revortopedia/article/view/1108

Issue

Section

Presentación de casos