Gonarthrosis and obesity
Keywords:
obesity, gonarthrosis, diet, body weight reduction, bariatric surgery.Abstract
Introduction: Gonarthrosis is a degenerative entity, with several modifiable and nonmodifiable factors. Among the former is obesity, which hinders the treatment of patients.
Objective: To update knowledge on patients with gonarthrosis and obesity.
Methods: The search and analysis of the information was carried out in three months. The terms osteoarthritis and obesity, knee osteoarthritis and obesity, obesity and treatment were used. A total of 423 articles were reviewed in the databases PubMed, Hinari, SciELO and Medline, using the EndNote search engine and reference manager.
Results: Patients with gonarthrosis, as well as the interrelation of biomechanical and biochemical elements, were characterized from a clinical point of view. The anatomical relationships of the knee in patients with obesity were described. Hormones acting in these patients and methods of treatment were pointed out.
Conclusions: Obesity associated with gonarthrosis is a poor prognostic factor, in terms of presentation and bilaterality of the disease. Also, it has been recognized as a factor of progression. Therefore, methods for its treatment in this group of patients must be carefully selected. The multidisciplinary team plays a very important role in this regard.
Downloads
References
Dickson BM, Roelofs AJ, Rochford JJ, Wilson HM, De Bari C. The burden of metabolic syndrome on osteoarthritic joints. Arthritis Res Ther. 2019;21(1):289. DOI: https://doi.org/10.1186/s13075-019-2081-x
Gudbergsen H, Overgaard A, Henriksen M, Wæhrens EE, Bliddal H, Christensen R, et al. Liraglutide after diet-induced weight loss for pain and weight control in knee osteoarthritis: a randomized controlled trial. Am J Clin Nutr. 2021;113(2):314-23. DOI: https://doi.org/10.1093/ajcn/nqaa328
Gundogdu G, Gundogdu K, Miloglu FD, Tasci SY. A new perspective on the relation between obesity and knee osteoarthritis: omentin. Curr Rheumatol Rev. 2020;16(4):324-31. DOI: https://doi.org/10.2174/1573397116666191226122801
Vennu V, Alenazi AM, Abdulrahman TA, Binnasser AS, Bindawas SM. Obesity and multisite pain in the lower limbs: data from the osteoarthritis initiative. Pain Res Manag. 2020;2020:6263505. DOI: https://doi.org/10.1155/2020/6263505
Godziuk K, Woodhouse LJ, Prado CM, Forhan M. Clinical screening and identification of sarcopenic obesity in adults with advanced knee osteoarthritis. Clin Nutr ESPEN. 2020;40:340-8. DOI: https://doi.org/10.1016/j.clnesp.2020.08.005
Georgiev T, Angelov AK. Modifiable risk factors in knee osteoarthritis: treatment implications. Rheumatol Int. 2019;39(7):1145-57. DOI: https://doi.org/10.1007/s00296-019-04290-z
Hunter DJ, Bierma-Zeinstra S. Osteoarthritis. Lancet. 2019;393(10182):1745-59. DOI: https://doi.org/10.1016/S0140-6736(19)30417-9
Messier SP, Beavers DP, Mihalko SL, Miller GD, Lyles MF, Hunter DJ, et al. The effects of intensive dietary weight loss and exercise on gait in overweight and obese adults with knee osteoarthritis. The Intensive Diet and Exercise for Arthritis (IDEA) trial. J Biomech. 2020;98:109477. DOI: https://doi.org/10.1016/j.jbiomech.2019.109477
Assari S, Bazargan M, Chalian M. The unequal effect of income on risk of overweight/obesity of whites and blacks with knee osteoarthritis: the osteoarthritis initiative. J Racial Ethn Health Disparities. 2020;7(4):776-84. DOI: https://doi.org/10.1007/s40615-020-00719-5
Collins KH, Lenz KL, Pollitt EN, Ferguson D, Hutson I, Springer LE, et al. Adipose tissue is a critical regulator of osteoarthritis. Proc Natl Acad Sci. 2021;118(1):e2021096118. DOI: https://doi.org/10.1073/pnas.2021096118
Jacobs CA, Vranceanu AM, Thompson KL, Lattermann C. Rapid progression of knee pain and osteoarthritis biomarkers greatest for patients with combined obesity and depression: data from the osteoarthritis initiative. Cartilage. 2020;11(1):38-46. DOI: https://doi.org/10.1177/1947603518777577
Bennell KL, Nelligan RK, Kimp AJ, Wrigley TV, Metcalf B, Kasza J, et al. Comparison of weight bearing functional exercise and non-weight bearing quadriceps strengthening exercise on pain and function for people with knee osteoarthritis and obesity: protocol for the TARGET randomised controlled trial. BMC Musculoskelet Disord. 2019;20(1):291. DOI: https://doi.org/10.1186/s12891-019-2662-5
Timmins KA, Leech RD, Batt ME, Edwards KL. Running and knee osteoarthritis: a systematic review and meta-analysis. Am J Sports Med. 2017;45(6):1447-57. DOI: https://doi.org/10.1177/0363546516657531
Conrozier T, Eymard F, Chouk M, Chevalier X. Impact of obesity, structural severity and their combination on the efficacy of viscosupplementation in patients with knee osteoarthritis. BMC Musculoskelet Disord. 2019;20(1):376. DOI: https://doi.org/10.1186/s12891-019-2748-0
Wilfong JM, Badley EM, Power JD, Gandhi R, Rampersaud YR, Perruccio AV. Discordance between self-reported and performance-based function among knee osteoarthritis surgical patients: Variations by sex and obesity. PLoS One. 2020;15(7):e0236865. DOI: https://doi.org/10.1371/journal.pone.0236865
Alrushud AS, Rushton AB, Kanavaki AM, Greig CA. Effect of physical activity and dietary restriction interventions on weight loss and the musculoskeletal function of overweight and obese older adults with knee osteoarthritis: a systematic review and mixed method data synthesis. BMJ Open. 2017;7(6):e014537. DOI: https://doi.org/10.1136/bmjopen-2016-014537
Dantas LO, Salvini TF, McAlindon TE. Knee osteoarthritis: key treatments and implications for physical therapy. Braz J Phys Ther. 2021;25(2):135-46. DOI: https://doi.org/10.1016/j.bjpt.2020.08.004
Senol O, Gundogdu G, Gundogdu K, Miloglu FD. Investigation of the relationships between knee osteoarthritis and obesity via untargeted metabolomics analysis. Clin Rheumatol. 2019;38(5):1351-60. DOI: https://doi.org/10.1007/s10067-019-04428-1
Jang S, Lee K, Ju JH. Recent updates of diagnosis, pathophysiology, and treatment on osteoarthritis of the knee. Int J Mol Sci. 2021;22(5):2619. DOI: https://doi.org/10.3390/ijms22052619
González F, Mustafa O, Antezana A. Alteraciones biomecánicas articulares en la obesidad. Gac Med Bol. 2011 [acceso 20/09/2022];34(1). Disponible en: http://www.scielo.org.bo/scielo.php?script=sci_arttext&pid=S1012-29662011000100014
Hill DS, Freudmann M, Sergeant JC, Board T. Management of symptomatic knee osteoarthritis in obesity: a survey of orthopaedic surgeons' opinions and practice. Eur J Orthop Surg Traumatol. 2018;28(5):967-74. DOI: https://doi.org/10.1007/s00590-017-2103-9
Joseph GB, Ramezanpour S, McCulloch CE, Nevitt MC, Lynch J, Lane NE, et al. Weight cycling and knee joint degeneration in individuals with overweight or obesity: four-year magnetic resonance imaging data from the osteoarthritis initiative. Obesity (Silver Spring). 2021;29(5):909-18. DOI: https://doi.org/10.1002/oby.23129
Raud B, Gay C, Guiguet-Auclair C, Bonnin A, Gerbaud L, Pereira B, et al. Level of obesity is directly associated with the clinical and functional consequences of knee osteoarthritis. Sci Rep. 2020;10(1):3601. DOI: https://doi.org/10.1038/s41598-020-60587-1
Loef M, van der Geest RJ, Lamb HJ, de Mutsert R, le Cessie S, Rosendaal FR, et al. Mediation of the association between obesity and osteoarthritis by blood pressure, vessel wall stiffness and subclinical atherosclerosis. Rheumatology (Oxford). 2021;60(7):3268-77. DOI: https://doi.org/10.1093%2Frheumatology%2Fkeaa778
Rafiq MT, Hamid MSA, Hafiz E, Chaudhary FA, Khan MI. Feasibility and acceptability of instructions of daily care in overweight and obese knee osteoarthritis participants. Curr Rheumatol Rev. 2021;17(4):421-7. DOI: https://doi.org/10.2174/1573397117666210727095552
Hart HF, van Middelkoop M, Stefanik JJ, Crossley KM, Bierma-Zeinstra S. Obesity is related to incidence of patellofemoral osteoarthritis: the Cohort Hip and Cohort Knee (CHECK) study. Rheumatol Int. 2020;40(2):227-32. DOI: https://doi.org/10.1007/s00296-019-04472-9
Lee BJ, Yang S, Kwon S, Choi KH, Kim W. Association between metabolic syndrome and knee osteoarthritis: A cross-sectional nationwide survey study. J Rehabil Med. 2019;51(6):464-70. DOI: https://doi.org/10.2340/16501977-2561
Rai MF, Sandell LJ, Barrack TN, Cai L, Tycksen ED, Tang SY, et al. A Microarray study of articular cartilage in relation to obesity and severity of knee osteoarthritis. Cartilage. 2020;11(4):458-72. DOI: https://doi.org/10.1177/1947603518796122
Fortuna R, Hart DA, Sharkey KA, Schachar RA, Johnston K, Reimer RA. Effect of a prebiotic supplement on knee joint function, gut microbiota, and inflammation in adults with co-morbid obesity and knee osteoarthritis: study protocol for a randomized controlled trial. Trials. 2021;22(1):255. DOI: https://doi.org/10.1186/s13063-021-05212-w
Boer CG, Radjabzadeh D, Medina C, Garmaeva S, Schiphof D, Arp P, et al. Intestinal microbiome composition and its relation to joint pain and inflammation. Nat Commun. 2019;10(1):4881. DOI: https://doi.org/10.1038/s41467-019-12873-4
Lawford BJ, Bennell KL, Allison K, Schwartz S, Hinman RS. Challenges with strengthening exercises for individuals with knee osteoarthritis and comorbid obesity: a qualitative study with patients and physical therapists. Arthritis Care Res (Hoboken). 2022;74(1):113-25. DOI: https://doi.org/10.1002/acr.24439
Üstün I, Solmaz A, Gülçiçek OB, Kara S, Albayrak R. Effects of bariatric surgery on knee osteoarthritis, knee pain and quality of life in female patients. J Musculoskelet Neuronal Interact. 2019 [acceso 20/09/2022];19(4):465-71. Disponible en: https://pubmed.ncbi.nlm.nih.gov/31789297/
Christensen R, Henriksen M, Leeds AR, Gudbergsen H, Christensen P, Sørensen TJ, et al. Effect of weight maintenance on symptoms of knee osteoarthritis in obese patients: a twelve-month randomized controlled trial. Arthritis Care Res (Hoboken). 2015;67(5):640-50. DOI: https://doi.org/10.1002/acr.22504
Hacken B, Rogers A, Chinchilli V, Silvis M, Mosher T, Black K. Improvement in knee osteoarthritis pain and function following bariatric surgery: 5-year follow-up. Surg Obes Relat Dis. 2019;15(6):979-84. DOI: https://doi.org/10.1016/j.soard.2019.04.005
