Factors associated with bone consolidation
Keywords:
bone consolidation, bone callus, diamond concept.Abstract
Introduction: Bone healing is a tissue regeneration process, which is influenced by multiple biological and biomechanical processes. It is a challenge for both physicians and scientists.
Objectives: To update information on factors associated with the bone consolidation process.
Methods: A retrospective review was conducted on scientific advances related to the bone consolidation process in the Medline database, certified by the Ministry of Science, Technology and Environment.
Development: Bone has regeneration potential in adult life with considerable intrinsic repair capacities. The cortex, periosteum, bone marrow and external soft tissues contribute to the healing process. The fracture hematoma is a source of signaling molecules. A sufficient cell population with high vitality allows the fractured bone to evolve towards its repair. The extracellular matrix provides the scaffolding for cellular events and interactions. Mechanical stability is considered a crucial factor for bone healing. These four elements constitute the Diamond concept.
Conclusions: The process of bone consolidation is a complex phenomenon: vascularity and individual characteristics constitute the basis on which other determinants act, such as osteoprogenitor cells, osteoinductive mediators and matrix, and sufficient mechanical stability.
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References
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